Christina Applegate experienced a minor health complication while filming Netflix series Dead To Me in 2019, years prior to being diagnosed with Multiple Sclerosis, that she now recognizes as the "first sign" of the life-altering autoimmune condition.

The Bad Moms actress zoomed in on the inconspicuous incident during the latest episode of iHeartRadio podcast MeSsy with Christina Applegate & Jamie-Lynn Sigler with guest and Dead To Me creator Liz Feldman.

"I remember falling that day. Hi, first sign of MS! So, not to bring everybody down, but there it was."

Applegate and Feldman spend a lot of time together amid filming the popular series that ran from 2019 to 2022, per The Daily Mail, and Feldman remembers concerning things the Anchorman standout would do that were quickly written off as exhaustion.

"I remember you losing your balance when we were shooting the pilot a couple of times. It was very hard to figure it out because, you know, I remember one time, it was really late at night. We'd been shooting probably 14 or 15 hours … it seemed completely reasonable that anybody would be collapsing."

Feldman continued:

"I could just sense A, that she was scared, and B, that something was wrong … that something in her body was not working the way that she wanted it to. There's no handbook for this. I can't compare it to any experience I've ever gone through with a person before."

Applegate was officially diagnosed with MS in 2021 and has since been very open about her physical and mental heath, with many of her podcast episodes bringing awareness to the unfortunate nervous system disorder.

Check out Feldman's full episode of MeSsy with Christina Applegate & Jamie-Lynn Sigler on iHeartRadio for more.

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